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Ziprasidone or Zeldox Capsule Uses Side Effects complete details

Ziprasidone or Zeldox Capsule Uses Side Effects and Complete Information:

  • Brand name: Geodon, Zeldox
  • Generic name: Ziprasidone
  •  Drug Class: Atypical Antipsychotics


Disorders such as schizophrenia and bipolar disorder can seriously affect emotions, comprehension and behavior. These mental illnesses are often accompanied by problems such as depression and substance abuse and can significantly affect the quality of life of patients and caregivers. disturbances have been introduced to the market since the fulfillment of chlorpromazine antipsychotic properties in 1952.

Ziprasidone is used to cure schizophrenia and bipolar diseases. It can effectively reduce the amount and time of relapse in schizophrenia and can be used to treat manic episodes in bipolar disorder even though the mechanism is unknown.

  • Type: Small molecule
  • Groups: Approved
  • Weight: Average:412.936
  • Monoisotopic:412.112459711
  • Chemical formula:  C21H21ClN4OS

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Mechanism of action:

The effects of ziprasidone have been differentiated from other antipsychotics based on the preference and interaction of specific receptors. Ziprasidone binds serotonin-2A (5-HT2A) and dopamine D2

receptors in the same way as other atypical antipsychotics. But one major difference is that ziprasidone has a higher 5-HT2A / D2 receptor affinity compared to other antipsychotics such as olanzapine, quetiapine, risperidone and aripiprazole. Ziprasidone may bind in moderation to norepinephrine and serotonin sites which may also affect its antidepressant and anxiolytic activity.

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In the absence of food, the oral availability of ziprasidone is 60%, and absorption can be up to 100% if ziprasidone is taken with a diet containing at least 500 kcal. The difference in obtaining bioavailability has nothing to do with fatty food content and appears to be related to food intake because more absorption occurs with longer ziprasidone remaining in the stomach.

Distribution volume:

The surface volume of Ziprasidone distribution is 1.5 L / kg.

Protein binding:

Ziprasidone is a protein that binds more than 99% of the drug bound to plasma proteins, especially albumin and alpha1-acid glycoprotein.


Ziprasidone is highly concentrated in the liver less than 5% of the drug is excreted in the urine. drugs made by CYP3A4 because only 1/3 of the antipsychotic is absorbed by the CYP3A4 system.


There are different types of Ziprasidone

  • Olanazpine
  • Thiobenzodiazepenes
  • Clozapine
  • Resperidone
  • Benzisoheterazoles
  • Dibenzazepines
  • Quetiapine fumarate


Side effects of Ziprasidone

Geodon may cause serious side effects, including:

  • heartbeat increased.
  • flying in your bosom
  • shortness of breath
  • sudden dizziness
  • uncontrollable muscle movements on your face (chewing, lip marking, dizziness, tongue movement, blinking or eye movement)
  • any skin rash
  • fever
  • mouth sores
  • skin lesions
  • Sore throat
  • cough
  • breathing hard
  • increased thirst
  • increased urination
  • dry mouth
  • a fragrant breath
  • very strong muscles
  • high fever
  • sweat
  • agitation
  • confusion

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Geodon’s common side effects include:

  • dizziness
  • drowsiness
  • weakness
  • nausea
  • to clean
  • swallowing problem
  • I felt uneasy
  • trembling
  • vision problems
  • curved nose
  • a new or worse cough


Ziprasidone belongs to a class of drugs called antipsychotics. It is used to overcome the symptoms of schizophrenia and the manic phase of bipolar diseases. It works by adjusting the chemical balance in the brain involved in schizophrenia.

Special warning & precautions

You should not use ziprasidone if you have a heart rhythm problem, long QT syndrome, uncontrolled heart failure, or if you have recently had a heart attack.

Tell your doctor about all your current medications and anything you are starting or stopping. Due to the interaction of many drugs, some are not used together.

Stop taking ziprasidone and call your doctor right away if you have sudden dizziness, rapid or rapid heartbeat, chest tightness, shortness of breath, a new or worsening skin rash or fever, or swollen glands. Ziprasidone is not recommended for use in older adults with dementia-related to dementia.

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