Atorvastatin Lipitor Tablet Uses, Side Effects complete Details:

Brand name: Caduet, Lipitor
Generic name: Atorvastatin
Drug Class: HMG-CoA Reductase Inhibitors, Lipid-Lowering Agents, Statins

Introduction:

Atorvastatin is a lipid-reducing drug included in the pharmacological category of statin. By preventing the total production of cholesterol in the liver, statins reduce abnormal cholesterol and lipid levels, and ultimately reduce the risk of heart disease. Statin drugs competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase 8 which converts HMG-CoA to mevalonic acid. This modification is a critical metabolic action involved in producing many compounds involved in lipid metabolism and transport, including cholesterol, low-density lipoprotein (LDL) (sometimes called “bad cholesterol”), and low-density lipoprotein (VLDL). Determining statements is considered a normal practice for patients following any cardiac event.

Atorvastatin was first synthesized in 1985 by Drs. Bruce Roth was also approved by the FDA in 1996.33 Apentro-pentro-pyrrole 3 made up of two opposing moitions with an arch hectocyclic core unit and a 3,5-dihydroxypentanoyl side chain that is exactly the same as its parent compound. 34 Unlike other members of the statin group, atorvastatin is an active compound and therefore does not need to be activated.

Type: Small molecule
Groups: Approved
Weight: Average:558.6398
Monoisotopic:558.253000445
Chemical formula: C33H35FN2O5

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Mechanism of action:

Atorvastatin is a statin and a competitive inhibitor of the enzyme HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase, which converts HMG-CoA to mevalonate, a first step in lowering cholesterol levels. biosynthesis. , 8 Atorvastatin acts primarily on the liver, where a decrease in hepatic cholesterol triggers an increase in hepatic low-density lipoprotein (LDL) receptors, which increase LDL uptake into the liver. Atorvastatin also lowers Low-Low-Density Lipoprotein-Cholesterol (VLDL-C), serum triglycerides (TG) and Intermediate Density Lipoproteins (IDL), and the number of apolipoprotein B (where B) contains particles, but increases the concentration of Lipoprotein Cholesterol (HDL-C). These effects include improved endothelial function, improved stability of atherosclerotic plates, reduction of oxidative stress and inflammation, and inhibition of thrombogenic response. The findings have been found to bind antiosterically to β2 integratedin function-associated antigen-1 (LFA-1), which plays a key role in leukocyte trafficking and T cell activation.

Absorption:

Atorvastatin produces a dose-based and non-compliant pharmacokinetic profile. Very fast after oral administration.

Atorvastatin undergoes extensive first-pass metabolism in the wall of the gut and the liver, resulting in an absolute oral bioavailability of 14%.2 Plasma atorvastatin concentrations are lower (about 30% of Cmax and AUC) follow drug administration in the evening compared to morning. However, the reduction in LDL-C is the same regardless of the date of drug administration Atorvastatin administration with dietary effects on long Tmax and reduction of Cmax and AUC.Breast Cancer Protein Protein (BCRP) is a membrane-bound protein that plays a key role in the production of atorvastatin. This has a significant impact on changes in drug response to efficacy and toxicity, especially such as BCRP.

Distribution volume:

The reported distribution volume of atorvastatin distribution is 380 L.

Protein binding:

Atorvastatin is highly binding to plasma proteins and more than 98% of the controlled dose is obtained by binding.

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Metabolism:

Atorvastatin is strongly associated with ortho- and parahydroxylated derivatives and various beta-oxidation products, most notably the Cytochrome P450 3A4 in the intestine and liver. These lactones can be rehydrated by hydrolyzed and return to their corresponding acid forms and exist equally.The in vitro inhibition of ortho- and parahydroxylated metabolites of HMG-CoA reductase is similar to that of atorvastatin. About 70% of the inhibitory circulatory activity of HMG-CoA reductase is caused by active metabolites.

Types:

There are different types of Atrovastatin:

Atrovastatin (Lipitor)
fluvastatin (Lescol, Lescol XL)
lovastatin (Mevacor, Altoprev)
pravastatin (Pravachol)
rosuvastatin (Crestor)
simvastatin (Zocor).
pitavastatin (Livalo)

Uses:

Hyperlipidemia
Hyperlipoproteinemia Type IIa (High LDL).
Hyperlipoproteinemia type IIb (Elevated LDL + VLDL).
Hyperlipoproteinemia Type III (beta-VLDL + high IDL).
Hyperlipoproteinemia IV (Elevenated VLDL).
Homozygous Familial
Hypercholesterolemia
Hypertriglyceridemia
Prevention of heart disease
Heterozygous Familial Hypercholesterolemi

Side effects of Atrovastatin:

Serious side effects include:

pain or heat when urinating.
abdominal pain.
weakness.
feel tired.
loss of food.
black urine.
yellowing of the skin or eyes (jaundice).
little or no urination.
swelling in your feet or ankles.
shortness of breath.
Get medical help fast, if you have any of the symptoms listed above.

Common side effects include:

joint pain
full nose
Sore throat
diarrhea
pain in arms or legs

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Description:

Lipitor is a prescription drug used to lower blood levels of “bad” cholesterol (low-density lipoprotein, or LDL), to raise levels of “good” cholesterol (high-density lipoprotein, or HDL) , reduce triglycerides and treat symptoms of high cholesterol (hyperlipidemia) and reducing the risk of stroke, heart disease or other heart problems. Lipitor can be used alone or with other medications.

Special warning & precautions:

This drug comes with several warnings.

You should not take Lipitor if you are pregnant or breastfeeding, if you have liver disease, or if you have been treated badly by Lipitor in the past.
Stop taking Lipitor and tell your doctor immediately if you become pregnant.
Severe drug interactions can occur when certain drugs are used in combination with Lipitor.
Tell your health care provider about all the medications you are currently taking, and any medications you are starting or stopping.

Atorvastatin can cause a condition that leads to degeneration of skeletal muscle, which can lead to kidney failure. Call your doctor right away if you have unexplained muscle pain, mildness, or weakness especially if you have a fever, unusual tiredness, or dark urine.

Avoid foods high in fat or cholesterol. Lipitor will not work well in lowering your cholesterol if you do not follow a cholesterol reduction program. Lipitor starts working in about two weeks. Lipitor is only part of a complete medical program that includes diet, exercise, and weight control. Focus on your diet, medication, and exercise.